Clinical Trial: CTE Neuroimaging

The purpose of this research study is to provide an understanding of the pathophysiological processes involved in traumatic brain injury including chronic traumatic encephalopathy (CTE). We propose to use positron emission tomography (PET) imaging to examine pathology associated with neurodegeneration using radiotracers. We will combine the PET assessments with magnetic resonance imaging (MRI)-based High Definition Fiber Tracking (HDFT) to quantify and localize TBI-induced white matter injury.

Traumatic Brain Injury including CTE is a neurodegenerative disease linked to repetitive traumatic brain injury (TBI). At present, traumatic brain injury including CTE can only be confirmed on autopsy examination of the brain, as no current modalities exist to diagnose the condition during the life of the patient.

There is no non-invasive assessment of CTE, established characterization of the degenerative process, or proven treatment to slow or reverse the degeneration process. The imaging and research samples performed through this study will help researchers in defining the linkage of traumatic brain injury or CTE.

Participants in this study can be either male or female, ages 18-60 years of age.

For more information about this study please call Clinical Trials Information at 412-647-3685.