Ajay Niranjan, MD, MBA

Professor
Director, UPMC-Brain Mapping Center (MEG)
Associate Director, Center for Image-Guided Neurosurgery
Director, Radiosurgery Research


Ajay Niranjan

Contact

412-647-6781

Biography

Ajay Niranjan, MD, is a professor of neurological surgery at the University of Pittsburgh.

Dr. Niranjan received his medical training at the King George’s Medical College in Lucknow, India from 1980 to 1985, graduating with a bachelor of medicine and bachelor of surgery degree. Dr. Niranjan completed general surgery residency in 1989 and neurological surgery residency 1992. Dr. Niranjan joined the University of Pittsburgh as a fellow in image-guided neurosurgery in 1997 and completed his fellowship in 2000. He joined the faculty of neurological surgery in July of 2000.

Dr. Niranjan’s major research interest is in the development of presurgical brain mapping using magnetoencephalography (MEG). His other research interests include development of strategies to enhance the effect of radiosurgery on brain tumors. His laboratory has studied the radiobiological effects of radiation on brain-tumor microenvironment and has evaluated the effects of radiation on neural stem cells implantation in the brain.

Dr. Niranjan serves as principal investigator on the following two projects: “Multicenter Phase II Study of Border Zone Stereotactic Radiosurgery with Bevacizumab Chemotherapy in Patients with Recurrent or Progressive Glioblastoma Multiforme” and “A Safety and Feasibility Study of Minocycline Therapy for Management of Adverse Radiation Effects after Brain Metastases Radiosurgery.”

He has co-authored over 170 articles in refereed journals and over 80 book chapters. He has contributed guidelines for stereotactic radiosurgery for trigeminal neuralgia, pituitary adenomas, arteriovenous malformation, acoustic tumors, and brain metastases. He has edited three books.

Specialized Areas of Interest

Radiosurgery for benign and malignant brain tumors; radiosurgery for brain vascular malformations; radiosurgery for functional brain disorders; pre-surgical brain mapping using MEG.

Hospital Privileges

UPMC Presbyterian

Professional Organization Membership

American Clinical MEG Society 
Congress of Neurological Surgeons
International Stereotactic Radiosurgery Society

Education & Training

MBBS, King George’s Medical College, 1985
Residency, General Surgery, King George’s Medical College, 1989
Residency, Neurological Surgery, King George’s Medical College, 1992
Fellowship, University of Pittsburgh, 2000
MBA, University of Pittsburgh, 2009

Selected Publications

Niranjan A, Kano H, Iyer A, Kondziolka D, Flickinger JC, Lunsford LD. Role of adjuvant or salvage radiosurgery in the management of unresected residual or progressive glioblastoma multiforme in the pre-bevacizumab era. J Neurosurg 122(4):757-65, 2015.

Niranjan A, Laing EJ, Laghari FJ, Richardson RM, Lunsford LD. Preoperative magnetoencephalographic sensory cortex mapping. Stereotactic and functional neurosurgery 91(5):314-22, 2013.

Niranjan A, Gobbel G, Novotny J, Bhatnagar JP, Fellows W, Lunsford LD. Impact of decaying dose rate in gamma knife radiosurgery: in vitro study on 9L rat gliosarcoma cells. J Radiosurgery and SBRT 1(4):257-64, 2012.

Niranjan A, Kano H, Khan A, Kim IY, Kondziolka D, Flickinger JC, Lunsford LD. Radiosurgery for brain metastases from unknown primary cancers. Int J Rad Oncol Biol Phys 77(5):1457-62, 2010.

Niranjan A, Kano H, Mathieu D, Kondziolka D, Flickinger JC, Lunsford LD. Radiosurgery for craniopharyngioma. Int J Rad Oncol Biol Phys 78(1):64-71, 2010.

Niranjan A, Mathieu D, Flickinger JC, Kondziolka D, Lunsford LD. Hearing preservation after intracanalicular vestibular schwannoma radiosurgery. Neurosurg 2008;63(6):1054-62, 2008.

Niranjan A, Fellows W, Stauffer W, Burton EA, Hong CS, Lunsford LD, Kondziolka D, Glorioso JC, Gobbel GT. Survival of transplanted neural progenitor cells enhanced by brain irradiation. J Neurosurg 107(2):383-91, 2007.

Niranjan A, Wolfe D, Tamura M, Soares MK, Krisky DM, Lunsford LD, Li S, Fellows-Mayle W, DeLuca NA, Cohen JB, Glorioso JC. Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery. Mole Ther 8(4):530-42, 2003.

Niranjan A, Moriuchi S, Lunsford LD, Kondziolka D, Flickinger JC, Fellows W, Rajendiran S, Tamura M, Cohen JB, Glorioso JC. Effective treatment of experimental glioblastoma by HSV vector-mediated TNF alpha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration. Mole Ther 2(2):114-20, 2000. 

Niranjan A, Kondziolka D, Baser S, Heyman R, Lunsford LD. Functional outcomes after gamma knife thalamotomy for essential tremor and MS-related tremor. Neurol 55(3):443-6, 2000.

A complete list of Dr. Niranjan's publications can be reviewed through the National Library of Medicine's publication database.

Research Activities

1) Phase II Study of Border Zone SRS with Bevacizumab in Patients with Recurrent or Progressive Glioblastoma (GBM). Dr. Niranjan is the principal investigator on this clinical trial evaluating the concept of border zone radiosurgery in association with Bevacizumab. This study is currently open for recruitment. 

2) A Safety and Feasibility Study of Minocycline Therapy for Management of ARE after Brain Metastases Radiosurgery. Dr. Niranjan is the principal investigator on this clinical trial evaluating the safety and feasibility of minocycline in improving adverse radiation effects after radiosurgery in patients with brain metastases. This study is currently open for recruitment.

Media Appearances