Cerebrovascular Clinical Studies
As one of the country’s leading referral centers for cerebrovascular disease, UPMC participates in a wide range of clinical trials. Many of these studies are coordinated through the UPMC Stroke Institute in the Department of Neurology, which actively participates in trials of both ischemic and hemorrhagic stroke. This is a multi-disciplinary effort involving investigators and teams from the departments of neurology, neurological surgery, critical care medicine, and emergency medicine. Current clinical trials run through the UPMC Stroke Institute include (more detailed info on these trials will be included here soon):
Ischemic Stroke Studies
Carotid Revascularization for Primary Prevention of Stroke (CREST 2) Trial
Platelet-Oriented inhibition in New TIA and minor ischemic stroke (POINT) Trial
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial
A Study of the Efficacy and Safety of Activase (Alteplase) in Patients with Mild Stroke (PRISMS)
Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) Trial
Safety Evaluation of 3K3A-APC in Ischemic Stroke (NN104 RHAPSODY)
SolitaireTM FR as Primary Treatment for Acute Ischemic Stroke (SWIFT PRIME)
GORE HELEX Septal Occluder / GORE Septal Occluder for Patent Foramen Ovale (PFO) Closure in Stroke Patients- The Gore REDUCE Clinical Study
A Study of Modified Stem Cells in Stable Ischemic Stroke
Study to Examine the Effects of MultiStem in Ischemic Stroke
Computed Tomography Perfusion (CTP) to Predict Response to Recanalization in Ischemic Stroke Project (CRISP)
Trevo and Medical Management versus Medical Management Alone in Wakeup and Late Presenting Strokes (DAWN)
Patient-centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Trial
Glyburide Advantage in Malignant Edema and Stroke (GAMES) Trial
Hemorrhagic Stroke/Aneurysm Studies
Intra-arterial Vasospasm Trial (IVT)
Ultra 3 Registry
Low Profile Visualized Intraluminal Support Device (LVIS) Study
BARREL Vascular Reconstruction Device Study
Clot Lysis: CLEAR III Trial
STOP-IT (Using Spot-sign to predict hematoma growth)
Anti-hypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II) Trial
Minimally Invasive Surgery Plus rt-PA for Intracerebral Hemorrhage Evacuation (MISTIE-III) Trial