Charles E. Romero, MD

  • Clinical Assistant Professor
  • Medical Director, UPMC Hamot Comprehensive Stroke Program

Charles E. Romero, MD, joined the University of Pittsburgh in 2013 as a vascular and CAST-accredited neuroendovascular surgeon-neurologist specializing in the treatment of vessel diseases of the brain, including aneurysms, stroke, carotid artery stenosis, arteriovenous malformations and fistulas, cavernomas, and intracerebral hemorrhage using minimally invasive techniques. As director of UPMC Hamot’s comprehensive stroke program, Dr. Romero is responsible for leading a team that provides stroke care, develops policies and procedures, and ensures the highest quality of care. His team is also working vigorously to improve patient outcomes and educate patients and their families about cerebrovascular disease.

Dr. Romero completed his undergraduate work at Rutgers University. He received his medical degree from the Universidad Autonoma de Guadalajara School of Medicine.  He then completed an academic year of supervised clinical education and fifth pathway certification at New York Medical College.  Dr. Romero completed the neurology residency program at Tufts Medical Center in Boston followed by fellowships in both stroke and interventional neuroradiology at Lahey Clinic Hospital & Medical Center in Burlington, Massachusetts.

Dr. Romero has published numerous papers and book chapters, participated in clinical trials, and he has lectured at national conferences, medical institutions, and academic gatherings covering endovascular stroke care, groundbreaking research, and preventive health care. His research interests include clinical outcomes in the treatment of cerebrovascular disease and stroke prevention.

Specialized Areas of Interest

Ischemic stroke, intracranial aneurysms, arteriovenous malformations, arteriovenous fistulas, carotid stenosis, intracranial arterial stenosis, epistaxis, tumor embolization and minimally invasive treatment of spine fractures.

Board Certifications

American Board of Psychiatry and Neurology

Hospital Privileges

UPMC Hamot

Professional Organization Membership

American Academy of Neurology
American Association of Neurological Surgeons
Society of Neurointervention
Society of Vascular and Interventional Neurology
World Federation of Interventional and Therapeutic Neuroradiology

Education & Training

  • BS, Biology, Rutgers University, 1992
  • Postbaccalaureate Premedical Certification, Columbia University, 1994
  • MD, Universidad Autonoma de Guadalajara School of Medicine, 1999
  • Fifth Pathway Certification, New York Medical College, 2000
  • Residency, Neurology, Tufts Medical Center, 2005
  • Fellowship, Stroke, Lahey Clinic Hospital & Medical Center, 2006

Honors & Awards

  • Patient Awards, U.S. News & World Report, 2011

Research Activities

•Multicenter, international, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor asundexian (BAY 2433334) for the prevention of ischemic stroke in male and female participants aged 18 years and older after an acute non-cardioembolic ischemic stroke or high-risk TIA (OCEANIC-STROKE)
Phase 3 program of the Oral faCtor Eleven A iNhibitor asundexLan as novel anti-thrombotiC STROKE study.

Comparison of Anti-coagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
Two-stage Phase III trial randomizing subjects with stroke attributed to 70-99% intracranial atherosclerotic stenosis to 1. ticagrelor + aspirin, 2. low dose rivaroxaban + aspirin, 3. clopidogrel + aspirin. 

Protection against Emboli during caRotid artery stenting using a 3-in-1 delivery system comprised oF a pOst-dilation balloon, integRated eMbolic filter, and A Novel Carotid stEnt II (PERFORMANCE II)
Prospective, single-arm, multicenter clinical trial to evaluate the safety and effectiveness of the Neuroguard IEP System for the treatment of carotid artery stenosis.

Media Appearances