Robert M. Friedlander, MD

Robert Friedlander, MD, MA, is the Walter E. Dandy Distinguished Professor, chair of the University of Pittsburgh Department of Neurological Surgery and co-director of the UPMC Neurological Institute, positions he has held since 2010. Before coming to the University of Pittsburgh, Dr. Friedlander was a professor at Harvard Medical School. He was also vice-chair of neurosurgery, associate director of cerebrovascular surgery and co-director of the Neuroscience Research Center at the Brigham and Women’s Hospital in Boston.

Dr. Friedlander has received a number of significant academic awards, most significantly an induction into the prestigious National Academy of Medicine in 2019. Election to the academy is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service. He has also received the Bayer Cerebrovascular Award from the Joint Section of Cerebrovascular Surgery, the International Charcot Prize for Motor Neuron Diseases, the Award from the Academy of Neurological Surgeons, the H. Richard Winn Prize from the Society of Neurological Surgeons, and the Distinguished Chancellor University of Pittsburgh Research Award.

Dr. Friedlander is an elected member of the prestigious American Society for Clinical Investigation, and the Association of American Physicians. As a sign of his prominence as a clinician and scientist, Dr. Friedlander is one of a very select group of authors to have been invited by the New England Journal of Medicine to write both a basic science review (mechanisms of neuronal cell death), as well as a clinical review (management of AVMs). Clinically, Dr. Friedlander focuses on the operative management of complex cerebrovascular disorders, brain tumors and Chiari malformations.

Dr. Friedlander’s major research interests lie in the study of the mechanistic pathways of the caspase apoptosis gene family. His work includes the evaluation of treatment strategies for neurodegenerative diseases (Huntington’s and ALS), stroke, brain trauma, and spinal cord injury through the modulation of the caspase-family apoptotic pathways. He was first to demonstrate activation and a functional role of caspase cell death pathways in neurological diseases. His research has received significant media attention. His major work has been published in the highest impact journals, most notably four publications in Nature, two in Science, one in Nature Medicine, one in Nature Neuroscience and eight in PNAS. For over two decades, he has had continuous NIH support as a principal investigator, as well numerous foundation awards. He directs a busy and prolific laboratory.

Dr. Friedlander served on the National Advisory Council of the National Institutes of Neurological Disorders and Stroke (NINDS). Additionally, a rewarding aspect of Dr. Friedlander’s activities is his involvement in organized neurosurgery. He was a member of the executive committee of the Congress of Neurological Surgeons, as well as chair of the CNS Research Committee, the CNS Membership Committee, and the CNS Publications Committee. He directed the Society of Neurological Surgeons RUNN (Research Update in Neuroscience for Neurosurgeons) Course from 2004 to 2018 and served as chair of the Society of Neurological Surgeons research committee. He is a past chair of the AANS/CNS Joint Section of Cerebrovascular Surgery.

A native of Caracas, Venezuela, Dr. Friedlander came to the United States in 1983 and earned a joint BA and MA in biochemistry from Brandeis University in 1987. In 1991, he graduated from Harvard Medical School and went on to fulfill his internship in general surgery and residency in neurosurgery at Massachusetts General Hospital.

Dr. Friedlander's publications can be reviewed through the National Library of Medicine's publication database.